Inhibitors of Protein Biosynthesis

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Inhibitors of Protein Biosynthesis V. EFl?ECTS OF EMETINE ON PROTEIN AND NUCLEIC ACID BIOSYNTHESIS IN HELA CELLS*

Emetine is rapidly concentrated from the media by suspension cultures of HeLa cells, and it inhibits protein biosynthesis by 50% at a concentration in the media of 4 X 10m8 M. The synthesis of DNA is partially inhibited by emetine, but the primary effect of the alkaloid in HeLa cells appears to be on the biosynthesis of protein. In contrast to the effects of cycloheximide, the effects of emetin...

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Inhibitors of Protein Biosynthesis V. EFl?ECTS OF EMETINE ON PROTEIN AND NUCLEIC ACID BIOSYNTHESIS IN HELA CELLS*

Emetine is rapidly concentrated from the media by suspension cultures of HeLa cells, and it inhibits protein biosynthesis by 50% at a concentration in the media of 4 X 10m8 M. The synthesis of DNA is partially inhibited by emetine, but the primary effect of the alkaloid in HeLa cells appears to be on the biosynthesis of protein. In contrast to the effects of cycloheximide, the effects of emetin...

متن کامل

Inhibitors of Protein Biosynthesis V. EFl?ECTS OF EMETINE ON PROTEIN AND NUCLEIC ACID BIOSYNTHESIS IN HELA CELLS*

Emetine is rapidly concentrated from the media by suspension cultures of HeLa cells, and it inhibits protein biosynthesis by 50% at a concentration in the media of 4 X 10m8 M. The synthesis of DNA is partially inhibited by emetine, but the primary effect of the alkaloid in HeLa cells appears to be on the biosynthesis of protein. In contrast to the effects of cycloheximide, the effects of emetin...

متن کامل

Inhibitors of protein biosynthesis. V. Effects of emetine on protein and nucleic acid biosynthesis in HeLa cells.

Emetine is rapidly concentrated from the media by suspension cultures of HeLa cells, and it inhibits protein biosynthesis by 50% at a concentration in the media of 4 X 10m8 M. The synthesis of DNA is partially inhibited by emetine, but the primary effect of the alkaloid in HeLa cells appears to be on the biosynthesis of protein. In contrast to the effects of cycloheximide, the effects of emetin...

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Lipid Biosynthesis Inhibitors

Five classes of herbicides (carbamothioates, chloroacetamides, substituted pyridazinones, cyclohexanediones, and aryloxyphenoxypropionic acids) have been reported to inhibit lipid biosynthesis in higher plants. Carbamothioates impair the synthesis of surface lipids (waxes, cutin, suberin). These effects have been attributed to the ability of this herbicide class to inhibit one or more acyl-CoA ...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1968

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(18)93283-7